A few years ago, the reversal agent, idarucizumab (Praxbind ®), became available to reverse the effects of dabigatran (Pradaxa ®, an oral direct thrombin inhibitor). Until recently, there has not been a specific reversal agent for these agents in the event of significant bleeding or an unexpected urgent procedure. These newer anticoagulants are at least as effective as warfarin and have a similar or decreased risk of bleeding – especially major bleeding.ĭespite the lower risk of major bleeding with these agents, some risk remains and may increase due to trauma or major surgery.
For decades, warfarin was the only FDA-approved oral anticoagulant for stroke prevention in atrial fibrillation (Afib) and for the treatment and prevention of venous thromboembolism (VTE), but newer treatments have emerged in the form of direct oral anticoagulants (DOACs).
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